It could be easy to miss Nolan Bros Boxing and Fitness if you don’t know what you’re looking for.

Tucked away on a quiet row of warehouses in South Waltham, the gym’s brick façade hides a fighter’s paradise.

Inside, strobe lights streak across the floor and music blares overhead. A few athletes work out in the gym’s two rings while others pummel dozens of punching bags suspended from chains. Colorful flags — representing Lebanon, Brazil, Haiti, and other countries around the globe — line the walls.

It’s fight club meets night club. And it’s serious business. Overseeing it all are identical twins Mark and Matt Nolan, both middle school science teachers and— if they have their way — the future of a local boxing renaissance.

Their gym is the title sponsor of Saturday’s Fight Night at Fenway, set to be the first time America’s Most Beloved Ballpark has hosted a boxing event since 1956. It will also feature the first women’s boxing match in Fenway history. For the brothers, it’s a bit of a coup as they look to help revive Boston’s boxing scene.

“I’ve been doing amateur promotion for years. My first professional boxing show was less than a year ago,” Matt Nolan said. “So to go from nothing to Fenway is unheard of, literally.”

An ever-evolving sport

In 1956, Americans were hearing Elvis sing about his “Blue Suede Shoes” for the first time. Brockton’s legendary champion Rocky Marciano retired.

Since then, boxing has taken a backseat to football and mixed martial arts have taken up some of its real estate.

But in Boston, it appears to be having a bit of a moment. Matt Nolan said he believes this is as popular the sport has been locally since he was a young kid.

Still, boxing, like other high impact sports, has had to navigate a growing consensus about its risks. Multiple studies show that repeated head impacts, like those sustained in boxing, can cause chronic traumatic encephalopathy, a neurodegenerative disease.

Boston University’s CTE Center lists a current study exploring “how repeated head impacts from playing contact sports can lead to long-term thinking, memory, and mood problems.” Among those participants it seeks are former boxers over the age of 50.

The Nolans said they have seen some parents who are reluctant to let their kids box. But they also have professors and doctors who use the gym. And anyone who doesn’t want to take hits to the head can participate in boxing-styled conditioning classes.

Maybe most importantly, the brothers feel the benefits of the sport help balance out the dangers.

“Lots of young men and women tell us all the time, they’re like, 'I’m a better person, I feel more confident in every aspect of my life because of what boxing’s done for me,'” said Mark Nolan.

One of those people is 30-year-old Sheniell Rodriguez, who is originally from the Hudson area, whose majestic facial hair has earned him the nickname “The Bearded Wonder.” He’ll be on the card at Fenway Saturday.

But just a few years ago, he was ready to leave the sport after he took a hit that broke an orbital bone on his right side and temporarily took out his vision in that eye.

“When that happened, I was like, 'Man, I hate this sport. I don’t know why I got into it,'” Rodriguez said.

His sight still isn’t back to 100 percent in that eye, and each of his hands has had multiple broken bones. But boxing gives him a peace of mind and keeps his spirits from sinking low.

“Me coming back into this took all that away from me, you know what I mean? Like, all the anxiety and the depression and everything,” Rodriguez said, comparing boxing to the effects of therapy.

Another competitor on the card Saturday will be Rico DePaolis, who went pro just over three years ago.

DePaolis, who is from Watertown,has three young sons and said stepping into the ring at Fenway will be meaningful.

“You know, one day we’re gonna drive by that place and they [will] understand what the hell’s going on and I’m gonna say, 'Hey, your dad fought there,'” he said.

Beyond that, DePaolis said he’s thrilled that Saturday’s fights will elevate the Nolans and their gym.

A family tradition

Boxing is in the Nolans’ blood. Their dad was a boxing coach and on the board of directors at the Somerville Boxing Club in the 1980s.

“We kind of grew up there,” Mark Nolan said.

Their strategy for promotion has been simple: treat people right, book good fights and find venues worthy of the occasion. Venues like Fenway Park.

A lot has changed since the last time boxing was the main draw at this ballpark. But in many ways, the almost primal rush the sport gives has stayed the same.

It’s something that leads Matt Nolan to believe that boxing will never die.

“Something about, like, putting up your dukes, rolling up your sleeves and punching another guy in the face and getting punched in the face, it’s like a great equalizer in so many ways,” he said. “And I just don’t see humanity escaping that enough for it to ever be in a graveyard.”