It’s the end of an era in mobile advertising. Boston-based Jumptap is being acquired by Millennial Media out of Baltimore for over $200 million in stock. Jumptap got started in 2004, raised $120 million in venture funding, and is the last of the old guard of Boston mobile-ad tech companies. That group includes Third Screen Media, Enpocket, Quattro Wireless, and Where, all of which were bought by outside companies in recent years. But advertising on mobile devices is still a young field, and a new guard is starting to emerge.

In other innovation news…

-Bind Therapeutics is joining the parade of biotech companies going public. The Cambridge drug-delivery startup has filed plans for an $80 million IPO.

-Our startup of the week is Extreme Reach. The Needham video-ad distribution company is acquiring rival Digital Generation’s TV business, for just under half a billion dollars. Extreme Reach’s founding team came from FastChannel, which was bought by DG in 2006.

-And finally, Boston and Israeli cybersecurity company Trusteer is getting bought by IBM for a rumored $800 million. This is Big Blue’s 21st acquisition of a Massachusetts software company since 2003. The other trend here is that U.S. tech companies are increasingly investing in Israel. Keep an eye on that, especially in the fields of hardware, Internet, and security.