Jonathan Guffey has chiseled youthful looks and, at 32, does not have the haggard bearing of someone who has spent more than half his life hooked on opioids. That stint with the drug started at 15 and ended — he says for good — 22 months ago. He has a job working with his family in construction, but his work history is pockmarked by addiction.

"I've worked in a couple of factories for a short amount of time, probably just long enough to get the first check to get high off of," Guffey says.

I met Guffey at an event called Road to Redemption, a weekly free dinner and support meeting at a church in Muncie, Ind., for people in, or seeking, recovery. He says his habit was enabled by other users — family, friends, even a boss at a factory where he once worked.

"There [were] plenty of times when I wouldn't go to work there, and my boss would call me and he wouldn't even say anything about work, he would just want more opiates ... pills or whatever it was that I could get at the time," Guffey says.

Economists estimate 1.5 million working-age people are missing from the labor force, not working or looking for work. It is not clear to what extent the country's heroin and opioid painkiller epidemic is affecting declining participation, especially among prime-age men, but in many communities such as Muncie, it is clear that the proliferation of opioid abuse is having a big enough impact for employers and the community to take notice.

Those with opioid addictions tell strikingly similar stories, in which work takes a back seat to an intensifying compulsion for the drug. They're sleepy on them, and horribly sick when they aren't. They say the physical impact is worse than with other drugs. Those I interviewed described a deepening alienation that ultimately includes both family and work. In lieu of jobs, most say they eventually supported themselves by dealing drugs.

"I lived and breathed drugs" and shunned both work and relationships, says Jennifer Smith, who shows me a mugshot of herself six months ago, just before she got sober. In it, she is thinner, with dark bags under her eyes, looking a decade older than her 40 years. She says before the opioids, she worked as a bartender, but went years without a job once she started using.

"It feels like I lost a lifetime," she says.

Opioid use is less common and, in the aggregate, less lethal than alcohol. But the data show opioids affect users' work life more. Research from the National Safety Council and the NORC research group at the University of Chicago show opioid users miss twice as many days of work than those with alcohol addiction. According to Princeton economist Alan Kreuger, 47 percent of prime-age men not in the labor force used pain medication — and two-thirds of that subgroup used prescription drugs.

Melissa Wallace's ex-husband and three children all wrestle with various addictions. She also owns a small cleaning business that hires some people in recovery, so she's seen how the disease affects both workers and employers.

"There is the trust issue," she says. "Even if they're clean, can I trust this person in peoples' homes or businesses? Often times they relapse, so there's reliability — are they going to show up?"

Wallace, who works for Road to Redemption, says opioid addiction strikes the rich, the poor, and the promising.

"I know a lot of my kids' friends have fallen into that trap — in and out of jail," she says. "Kids that, if you would've told me 10 years ago would have ended up in jail, I would've just been like, 'no way.' "

She might as well be talking about Kathryn Sexton. Sexton is a tall 23-year-old from an upper-middle class family whose perfect high school grades landed her a full-ride college scholarship.

"And that's where I met heroin," she says. "Next thing I know, I'm cocktail waitressing in a gentlemen's club, and it was instant money — and those are the types of things I would've never imagined myself doing."

She dropped out of college. She says among her circle of a dozen high school friends, seven are dead of opioid overdoses, or related car accidents or medical crises. Sexton sobered up a month ago, only to confront a felony possession charge that might cost her her nursing assistant's license — the only thing remaining of her career plans.

What's more, she says, it might mean she won't be able to go back to school, possibly ever.

"If these charges stick, I will not be able to get any federal loans, because they don't give them to felons," Sexton says.

Families will point out, it's not just the addicted whose careers suffer.

I meet Roger and Katiena Johnson on their front lawn, strewn with kids' toys — evidence they've been thrust back into parenting their two grandkids. Their 26-year-old daughter, Destini, went to jail on drug charges — but they describe her as a once hard-working teenager who previously had a job at the same company as her father.

"She's worked with me twice, when she was 16 years old and going to school," says Roger Johnson. "So, I mean, once this drug gets hold of you, it brings you down."

Katiena Johnson says she missed work days driving Destini to rehab and doctors, and that dealing with opioid addiction interrupted her own plans.

"Once you raise your kids, you want to be able to retire or something," she says. "We weren't able to; we went ahead and took on our grandkids," she says, before being interrupted by someone yelling, "Hey," in front of the house.

It's Destini Johnson, released unexpectedly early because, she tells her parents, the jail was overcrowded. Her mother, who works the overnight shift at a local children's home, wears an expression that is both happy and worried because Destini wasn't given a shot to control her opioid cravings. And once again, Katiena Johnson is rethinking her work schedule.

"Kind of makes me want to stay home tonight, just to make sure she doesn't use," she says, adding that she'll lean on other family members if necessary.

Destini Johnson surveys the doghouse where she slept when her parents evicted her for using in the house. She points to the side entrance of her parents' home, which is blocked by bags of her old clothes and other items she used to drag around when she was strung out and homeless.

She says sobriety in jail made her realize she wants a good job, but that in the past, addiction meant she was also hooked on making the quick buck.

"I'd rather go and trick," she says, looking at me. "I don't know if you know what that is, but you know, have sex for money to get my drugs, because it was a lot faster and easier," she explains. "You have to wait a whole week for a paycheck — no addict wants to wait that long to get their drugs."

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