The National Institutes of Health is overhauling the leadership of its world-renowned Clinical Center, after an independent task force found the center was putting research ahead of patient safety.

As NPR's Nell Greenfieldboyce has reported, the Clinical Center in Bethesda, Md., is the largest research hospital in the world. Patients come from across the country seeking its experimental therapies. But a recent independent review found safety problems at two laboratories, including one run by Dr. Steven Rosenberg, a world-renowned researcher at the National Cancer Institute. Rosenberg is a pioneer in cancer immunotherapy, which harnesses the body's own immune system to fight disease.

In 2015, the NIH was forced to close the Clinical Center's in-house pharmaceutical production facility after inspectors found fungal contamination, insects in light fixtures and problems in the air-handling system. That incident prompted the formation of an independent task force to review the Clinical Center's operations.

In its report issued this spring, the task force concluded that researchers were more preoccupied with their scientific studies than with the safety of the patients enrolled in the center's clinical trials. "The emphasis on research is so great, and on trying to save people's lives, that there became a cultural attitude that overshadowed handling some of the details that are important details," Norman Augustine, who chaired the task force, told Greenfieldboyce.

While the safety deficiencies put patients at risk, no one is believed to have been harmed by the problems, according to the task force report.

Following the report's recommendations, the NIH will create three new leadership positions to oversee the Clinical Center. One of those positions will be a new chief executive officer. "NIH will begin a nationwide search for a physician CEO with proven experience in management of a complex inpatient and outpatient facility," the agency said in a statement provided to NPR over e-mail.

Copyright 2016 NPR. To see more, visit