Republicans in the state Legislature are calling for the departure of JudyAnn Bigby, the state's health and human services secretary.
In a letter sent on Thursday to Gov. Deval Patrick, House Republicans cited "poor management" in the aftermath of two recent crises: The alleged tampering with drug tests at a former Department of Public Health lab, and a deadly outbreak of fungal meningitis linked to a Framingham compounding pharmacy that was regulated by the state.
Minority leader Brad Jones said at a news conference on Thursday that the agency desperately needs new leadership.
The GOP called on Patrick to remove Bigby if she does resign.
A spokesman for the secretary said Bigby serves at the pleasure of the governor and will continue to take the necessary steps to restore public confidence in the agency.