U.S. Secretary of State John Kerry speaks to the press prior to talks with Japanese Foreign Minister Fumio Kishida at the State Department in Washington on Friday.

RACHEL MARTIN, HOST:

This is WEEKEND EDITION from NPR News. I'm Rachel Martin. It's a big week for U.S. foreign policy. America's new top diplomat makes his first official trip overseas and international talks resume over Iran's nuclear program. Both diplomatic events are about managing expectations around two of the world's trouble spots: Syria and Iran. We begin with Secretary of State John Kerry and his nine-country tour of Europe and the Middle East. NPR's Michele Kelemen has the story.

MICHELE KELEMEN, BYLINE: Secretary Kerry is portraying his first trip as a listening tour and he certainly expects to hear a lot about Syria. He told reporters recently that he wants to talk with U.S. allies about how to persuade Bashar al-Assad to agree on peace talks that would end Assad's bloody rule in Syria.

SECRETARY JOHN KERRY: My goal is to see us change his calculation. My goal is to see us have a negotiated outcome and minimize the violence. It may not be possible.

KELEMEN: But Kerry needs to find out says a former State Department official, Frederic Hof, now a senior fellow at the Rafik Hariri Center for the Middle East at the Atlantic Council.

FREDERIC HOF: The primary purpose here, I think, is due diligence. It's to check an important box as to whether or not a peaceful, managed political transition in Syria, a negotiated process, is actually possible.

KELEMEN: This past week, Russian Foreign Minister Sergei Lavrov, along with the head of the Arab League, offered to broker talks between the Syrian government and the opposition.

SERGEI LAVROV: (Foreign language spoken)

KELEMEN: Neither side can rely on a military solution to the conflict, Lavrov argues because in his words that's a road to nowhere, a road to mutual destruction of the people. Lavrov will be meeting Secretary Kerry in Berlin this week and Kerry will likely use the opportunity to encourage Russia, once again, to use its influence with Assad. Kerry will also be visiting Rome, where he will have a chance to meet Syrian opposition figures. The Atlantic Council's Hof says the Syrian opposition council leader Moaz al-Khatib has made clear he's ready for negotiations.

HOF: He asked for a major prisoner release but he did not demand that Assad resign first. And this is potentially very significant. He took a big risk with his own followers who understandably want Assad gone up front.

KELEMEN: Hof has his doubts that this diplomatic effort will get very far, though, and if it doesn't, he says, the Obama administration will have to think again about how to support the opposition, whether with arms or intelligence sharing.

HOF: If Senator Kerry comes to the conclusion that there's no there there, I suspect he will come back, he'll report to the president and he may well propose a significant readjustment of U.S. policy towards Syria. And that might be the thing that could have the effect of changing Assad's calculation.

KELEMEN: After visiting London, Berlin, Paris, Rome and Ankara, Kerry is to visit several Gulf States. The vice president of the Woodrow Wilson Center, Aaron David Miller, says this is a relatively risk-free trip.

AARON DAVID MILLER: It's safe, centrist and very secretarial.

KELEMEN: But Kerry does have one risky stop - Egypt - and experts will be watching how the new secretary deals with the struggling Islamist government there. Michele Kelemen, NPR News, Washington. Transcript provided by NPR, Copyright NPR.